Enhanced B-cell differentiation driven by advanced cirrhosis resulting in hyperglobulinemia

Author:

Doi Hiroyoshi12ORCID,Hayashi Eiichi1,Arai Jun1,Tojo Masayuki1,Morikawa Kenichi3ORCID,Eguchi Junichi4,Ito Takayoshi4,Kanto Tatsuya2,Kaplan David E5,Yoshida Hitoshi1

Affiliation:

1. Division of Gastroenterology, Department of Medicine; Showa University School of Medicine; Shinagawa Tokyo Japan

2. National Center for Global Health and Medicine; The Research Center for Hepatitis and Immunology; Ichikawa Japan

3. Hokkaido University Graduate School of Medicine; Sapporo Japan

4. Showa University Koto Toyosu Hospital; Toyosu Tokyo Japan

5. Division of Gastroenterology, Department of Medicine; University of Pennsylvania; Philadelphia Pennsylvania USA

Funder

Grant-in-Aid for Young Scientists B

Publisher

Wiley

Subject

Gastroenterology,Hepatology

Reference42 articles.

1. Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance;Albillos;J Hepatol. European Association for the Study of the Liver,2014

2. Immune dysfunction and infections in patients with cirrhosis;Bonnel;Clin. Gastroenterol. Hepatol.,2011

3. Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population;Doi;Hepatology,2012

4. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals;Moir;J. Exp. Med.,2008

5. Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with cirrhosis;Chang;Sci. Rep. Nature Publishing Group,2016

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