Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2antagonist in clinical development for asthma-Reference-Cited by-同舟云学术

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Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2antagonist in clinical development for asthma

Published:2013-03-12 Issue:7 Volume:168 Page:1626-1638
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Schmidt JA¹,Bell FM¹,Akam E¹,Marshall C¹,Dainty IA²,Heinemann A³,Dougall IG¹,Bonnert RV⁴,Sargent CA¹

Affiliation:

1. Department of Bioscience; AstraZeneca R&D Charnwood; Loughborough; Leicestershire; UK

2. Department of Bioscience; AstraZeneca R&D Mölndal; Mölndal; Sweden

3. Institute of Experimental and Clinical Pharmacology; Medical University of Graz; Graz; Austria

4. Department of Medicinal Chemistry; AstraZeneca R&D Charnwood; Loughborough; Leicestershire; UK

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12053/fullpdf

Reference61 articles.

1. Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family;Abe;Gene,1999

2. Guide to Receptors and Channels (GRAC), 5th Edition;Alexander;Br J Phamacol,2011

3. Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses;Angeli;J Immunol,2004

4. Release of 15-keto-13,14-dihydro-thromboxane B2 and prostaglandin D 2 during anaphylaxis as measured by radioimmunoassay;Anhut;Naunyn Schmiedebergs Arch Pharmacol,1978

5. Arimura A 2010 Discovery of a First-in-Class Drug, a Prostaglandin D2 Antagonist, for the Treatment of Allergic Diseases Molecular Imaging for Integrated Medical Therapy and Drug Development Part IV 281 287

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2. DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time;Scientific Reports;2024-04-08

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4. In VitroBiology: Measuring Pharmacological Activity that Will Translate to Clinical Efficacy;The Handbook of Medicinal Chemistry;2023-02-03

5. Efficacy of an oral CRTH2 antagonist (AZD1981) in the treatment of chronic rhinosinusitis with nasal polyps in adults: A randomized controlled clinical trial;Clinical & Experimental Allergy;2022-05-18

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