In-solution direct oxidative coupling for the integration of sulfur/selenium into DNA-encoded chemical libraries

Author:

Yang Shilian1ORCID,Zhao Guixian1ORCID,Gao Yuting1ORCID,Sun Yang1ORCID,Zhang Gong12ORCID,Fan Xiaohong13ORCID,Li Yangfeng12ORCID,Li Yizhou124ORCID

Affiliation:

1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China

2. Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China

3. Pharmaceutical Department of Chongqing Three Gorges Central Hospital, Chongqing University, Chongqing, 404100, P. R. China

4. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, P. R. China

Abstract

DNA-compatible direct oxidative coupling using various sulfur/selenium sources has been achieved, featuring pre-functionalization-free substrates and transition metal-free condition.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Natural Science Foundation of Chongqing

Fundamental Research Funds for the Central Universities

Beijing National Laboratory for Molecular Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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