Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

Author:

Devriese Lot A.12,Witteveen Petronella Els. O.3,Mergui-Roelvink Marja2,Smith Deborah A.4,Lewis Lionel D.5,Mendelson David S.6,Bang Yung-Jue7,Chung Hyun Choel8,Dar Mohammed M.4,Huitema Alwin D. R.9,Beijnen Jos H.910,Voest Emile E.3,Schellens Jan H. M.1210

Affiliation:

1. Division of Experimental Therapy; The Netherlands Cancer Institute; Amsterdam The Netherlands

2. Department of Clinical Pharmacology; The Netherlands Cancer Institute; Amsterdam The Netherlands

3. Department of Medical Oncology; University Medical Center Utrecht; The Netherlands

4. GlaxoSmithKline; Research Triangle Park USA

5. Department of Medicine, The Geisel School of Medicine at Dartmouth and The Norris Cotton Cancer Center; Dartmouth-Hitchcock Medical Center; Lebanon USA

6. Pinnacle Oncology Hematology; Scottsdale USA

7. Department of Internal Medicine; Seoul National University College of Medicine; Seoul South Korea

8. Yonsei Cancer Center; Severance Hospital; Seoul South Korea

9. Department of Pharmacy & Pharmacology; Slotervaart Hospital; Amsterdam The Netherlands

10. Science Faculty, Department of Pharmaceutical Sciences; Utrecht University; The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference40 articles.

1. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin;Hsiang;Cancer Res,1988

2. Topoisomerase I inhibitors: camptothecins and beyond;Pommier;Nat Rev Cancer,2006

3. Oral topotecan given once or twice daily for ten days: a phase I pharmacology study in adult patients with solid tumors;Gerrits;Clin Cancer Res,1998

4. Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors;Creemers;J Clin Oncol,1997

5. A comparison of clinical pharmacodynamics of different administration schedules of oral topotecan (Hycamtin);Gerrits;Clin Cancer Res,1999

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