In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells

Author:

Pham Minh Quan12,Tran Thi Hoai Van234,Pham Quoc Long2,Gairin Jean Edouard1ORCID

Affiliation:

1. UPS UMR 152 Pharma‐DEV Université Toulouse 3 Faculté des Sciences Pharmaceutiques Université de Toulouse 35 Chemin des Maraîchers F‐31062 Toulouse France

2. Institute of Natural Products Chemistry Vietnam Academy of Science and Technology Building 1H, 18 Hoang Quoc Viet Hanoi Vietnam

3. Vietnam Academy of Science and Technology Graduate University of Science and Technology 18 Hoang Quoc Viet Hanoi Vietnam

4. Vietnam University of Traditional Medicine Ministry of Health 2 Tran Phu Hanoi Vietnam

Funder

Fondation ARC pour la Recherche sur le Cancer

National Foundation for Science and Technology Development

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference39 articles.

1. GLOBOCAN.International Agency for Cancer Research ‐ Liver cancer fact sheet 2012. Available from:http://globocan.iarc.fr/(accessed31 August 2018)

2. Treatment of Liver Cancer

3. Mortalin-p53 Interaction as a Target for Liver Cancer Therapy

4. An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?

5. Three faces of mortalin: A housekeeper, guardian and killer

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