Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor

Author:

Burdorf Lars1,Riner Andrea1,Rybak Elana1,Salles Isabelle I.23,De Meyer Simon F.2,Shah Aakash1,Quinn Kevin J.1,Harris Donald1ORCID,Zhang Tianshu1,Parsell Dawn1,Ali Franchesca1,Schwartz Evan1,Kang Elizabeth1,Cheng Xiangfei1,Sievert Evelyn1,Zhao Yuming1,Braileanu Gheorghe1,Phelps Carol J.4,Ayares David L.4,Deckmyn Hans2,Pierson Richard N.1,Azimzadeh Agnes M.1

Affiliation:

1. Division of Cardiac Surgery; Department of Surgery; University of Maryland School of Medicine and VA Maryland Health Care System; Baltimore MD USA

2. Laboratory for Thrombosis Research; IRF-Ls; Kulak KU Leuven; Leuven Belgium

3. Centre for Hematology; Imperial College; London UK

4. Revivicor Inc.; Blacksburg VA USA

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Revivicor, Inc

United Therapeutics, Inc

University of Maryland, Baltimore County

University of Maryland Clinical Translational Science Institute

University of Maryland General Clinical Research Center

Publisher

Wiley

Subject

Transplantation,Immunology

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1. Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood;Xenotransplantation;2023-09-28

2. Heart and Lung Xenotransplantation;Textbook of Transplantation and Mechanical Support for End‐Stage Heart and Lung Disease;2023-09-08

3. LUNG XENOTRANSPLANTATION: CURRENT STATUS 2023;European Journal of Transplantation;2023-09

4. Future of Lung Transplantation;Clinics in Chest Medicine;2023-03

5. Xenotransplantation: past, present, and future directions;Highlights in BioScience;2022-12-29

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