One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

Author:

Mohiuddin M. M.1,Singh A. K.1,Corcoran P. C.1,Hoyt R. F.2,Thomas M. L.3,Lewis B. G. T.3,Eckhaus M.3,Reimann K. A.4,Klymiuk N.5,Wolf E.5,Ayares D.6,Horvath K. A.1

Affiliation:

1. Cardiothoracic Surgery Research Program; NHLBI; NIH; Bethesda MD

2. Animal Surgery Research; NHLBI; NIH; Bethesda MD

3. Division of Veterinary Resources; ORS; NIH; Bethesda MD

4. MassBiologics; University of Massachusetts; Boston MA

5. Institute of Molecular Animal Breeding and Biotechnology; Ludwig-Maximilians-Universität München; Munich Germany

6. Revivicor, Inc.; Blacksburg VA

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference5 articles.

1. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience;Kuwaki;Nat Med,2005

2. B-cell depletion extends the survival of GTKO hCD46Tg pig heart xenografts in baboons for up to 8 months;Mohiuddin;Am J Transplant,2012

3. Comparison of Gal and non-Gal-mediated cardiac xenograft rejection;Tazelaar;Transplantation,2011

4. Coagulation dysregulation as a barrier to xenotransplantation in the primate;Lin;Transpl Immunol,2009

5. Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model;Mohiuddin;Xenotransplantation,2013

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