Antiallergic drug desloratadine as a selective antagonist of 5HT 2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction-Reference-Cited by-同舟云学术

Antiallergic drug desloratadine as a selective antagonist of 5HT 2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction

Published:2020-12-24 Issue:1 Volume:20 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Lu Jian¹^ORCID,Zhang Chuzhao¹,Lv Jianlu¹,Zhu Xialin¹,Jiang Xingwu²,Lu Weiqiang²,Lu Yin¹,Tang Zongxiang¹,Wang Jiaying¹,Shen Xu¹^ORCID

Affiliation:

1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine Nanjing China

2. Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai China

Publisher

Wiley

Subject

Cell Biology,Ageing

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13286

Reference45 articles.

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3. Inflammation, microglia, and alzheimer's disease

4. Desloratadine citrate disodium injection, a potent histamine H1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades

5. Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

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