Genetic and observational evidence: No independent role for cholesterol efflux over static high‐density lipoprotein concentration measures in coronary heart disease risk assessment

Author:

Kuusisto Sanna1234,Karjalainen Minna K.1245,Tillin Therese6,Kangas Antti J.7,Holmes Michael V.8,Kähönen Mika9,Lehtimäki Terho10,Viikari Jorma1112,Perola Markus131415,Chaturvedi Nishi6,Salomaa Veikko15,Raitakari Olli T.161718,Järvelin Marjo‐Riitta24192021,Kettunen Johannes12415,Ala‐Korpela Mika1234ORCID

Affiliation:

1. Computational Medicine Faculty of Medicine University of Oulu Oulu Finland

2. Center for Life Course Health Research Faculty of Medicine University of Oulu Oulu Finland

3. NMR Metabolomics Laboratory School of Pharmacy University of Eastern Finland Kuopio Finland

4. Biocenter Oulu University of Oulu Oulu Finland

5. Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies Faculty of Medicine University of Oulu Oulu Finland

6. MRC Unit for Lifelong Health and Ageing at UCL Institute of Cardiovascular Science University College London London UK

7. Nightingale Health Plc. Helsinki Finland

8. Medical Research Council Population Health Research Unit University of Oxford Oxford UK

9. Department of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center Tampere Faculty of Medicine and Health Technology Tampere University Tampere Finland

10. Department of Clinical Chemistry Fimlab Laboratories and Finnish Cardiovascular Research Center Tampere Faculty of Medicine and Health Technology Tampere University Tampere Finland

11. Department of Medicine University of Turku Turku Finland

12. Division of Medicine Turku University Hospital Turku Finland

13. Research Programs Unit Diabetes and Obesity University of Helsinki Helsinki Finland

14. Estonian Genome Center University of Tartu Tartu Estonia

15. Department of Public Health and Welfare Finnish Institute for Health and Welfare Helsinki Finland

16. Centre for Population Health Research University of Turku and Turku University Hospital Turku Finland

17. Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku Finland

18. Department of Clinical Physiology and Nuclear Medicine Turku University Hospital Turku Finland

19. Unit of Primary Health Care Oulu University Hospital (OYS) Oulu Finland

20. Department of Epidemiology and Biostatistics MRC‐PHE Centre for Environment and Health School of Public Health Imperial College London London UK

21. Department of Life Sciences, College of Health and Life Sciences Brunel University London London UK

Funder

Academy of Finland

Juho Vainion Säätiö

Paavo Nurmen Säätiö

Sydäntutkimussäätiö

Suomen Kulttuurirahasto

Emil Aaltosen Säätiö

Yrjö Jahnssonin Säätiö

Novo Nordisk Fonden

Publisher

Wiley

Subject

Internal Medicine

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