Selective inhibition of prostaglandin D 2 biosynthesis in human mast cells to overcome need for multiple receptor antagonists: Biochemical consequences

Author:

Johnsson Anna‐Karin12ORCID,Choi Jeong‐Hee12ORCID,Rönnberg Elin23ORCID,Fuchs David4ORCID,Kolmert Johan12ORCID,Hamberg Mats4,Dahlén Barbro5ORCID,Wheelock Craig E.4ORCID,Dahlén Sven‐Erik12ORCID,Nilsson Gunnar236ORCID

Affiliation:

1. Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

2. Centre for Allergy Research Karolinska Institutet Stockholm Sweden

3. Immunology and Allergy Division Department of Medicine Karolinska Institutet and Karolinska University Hospital Solna Sweden

4. Division of Physiological Chemistry 2 Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden

5. Department of Medicine Clinical Asthma and Allergy Research Laboratory Karolinska University Hospital Huddinge Sweden

6. Department of Medical Sciences Uppsala University Uppsala Sweden

Funder

Vetenskapsrådet

Hjärt-Lungfonden

Cancerfonden

Karolinska Institutet

Svenska Sällskapet för Medicinsk Forskning

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference44 articles.

1. Prostaglandin D2 generation after activation of rat and human mast cells with anti‐IgE;Lewis RA;J Immunol,1982

2. Arachidonic acid metabolism in purified human lung mast cells;Peters SP;J Immunol,1984

3. The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men

4. Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction

5. The possible role of prostaglandin D2in the long-lasting airways vasodilatation induced by allergen in the sensitized pig

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