Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L-Reference-Cited by-同舟云学术

Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L

Published:2012-10-09 Issue:6 Volume:80 Page:971-980
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:

Author:

Basavapathruni Aravind,Jin Lei,Daigle Scott R.,Majer Christina R. A.,Therkelsen Carly A.,Wigle Tim J.,Kuntz Kevin W.,Chesworth Richard,Pollock Roy M.,Scott Margaret P.,Moyer Mikel P.,Richon Victoria M.,Copeland Robert A.,Olhava Edward J.

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12050/fullpdf

Reference27 articles.

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2. Protein methyltransferases as a target class for drug discovery;Copeland;Nat Rev Drug Discov,2009

3. Chemogenetic analysis of human protein methyltransferases;Richon;Chem Biol Drug Des,2011

4. Protein methyltransferase inhibitors as personalized cancer therapeutics;Copeland;Drug Discov Today Ther Strateg,2011

5. MLL translocations, histone modifications and leukaemia stem-cell development;Krivtsov;Nat Rev Cancer,2007

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