Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain-Reference-Cited by-同舟云学术

Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain

Published:2015-12-11 Issue:2 Volume:30 Page:153-161
ISSN:0767-3981
Container-title:Fundamental & Clinical Pharmacology
language:en
Short-container-title:Fundam Clin Pharmacol

Author:

de Moraes Natália V.¹,Lauretti Gabriela R.²,Coelho Eduardo B.²,Godoy Ana Leonor P. C.³,Neves Daniel V.³,Lanchote Vera L.³

Affiliation:

1. Faculdade de Ciências Farmacêuticas; Universidade Estadual Paulista; ZIP 14801-902 Araraquara SP Brazil

2. Faculdade de Medicina de Ribeirão Preto; Universidade de São Paulo; ZIP 14049-900 Ribeirão Preto SP Brazil

3. Faculdade de Ciências Farmacêuticas de Ribeirão Preto; Universidade de São Paulo; ZIP 14040-903 Ribeirão Preto SP Brazil

Funder

Financiadora de Estudos e Projetos

Fundação de Apoio ao Ensino e Assistência do HCFMRP-USP (FAEPA)

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/fcp.12168/fullpdf

Reference41 articles.

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3. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor;Gillen;Naunyn Schmiedebergs Arch. Pharmacol.,2000

4. Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype;García-Quetglas;Pharmacol. Res.,2007

5. Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes;Subrahmanyam;Drug Metab. Dispos.,2001

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