Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6 , CYP2B6 , and CYP3A4 genotype

Author:

Haage Pernilla12ORCID,Kronstrand Robert12,Josefsson Martin13,Calistri Simona45,van Schaik Ron H. N.4,Green Henrik12,Kugelberg Fredrik C.12

Affiliation:

1. Department of Forensic Genetics and Forensic Toxicology; National Board of Forensic Medicine; Linköping Sweden

2. Department of Medical and Health Sciences; Division of Drug Research; Linköping University; Linköping Sweden

3. Department of Physics, Chemistry and Biology; Linköping University; Linköping Sweden

4. Department of Clinical Chemistry; Erasmus University Medical Center; Rotterdam The Netherlands

5. Scuola di Scienze della Salute Umana; Università degli studi di Firenze; Florence Italy

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference31 articles.

1. Clinical pharmacology of tramadol;Grond;Clin Pharmacokinet,2004

2. Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol;Raffa;J Pharmacol Exp Ther,1993

3. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor;Gillen;Naunyn Schmiedebergs Arch Pharmacol,2000

4. The pharmacogenetics of tramadol;Lassen;Clin Pharmacokinet,2015

5. Tramadol: seizures, serotonin syndrome, and coadministered antidepressants;Sansone;Psychiatry (Edgmont),2009

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