Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects-Reference-Cited by-同舟云学术

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Published:2017-11-17 Issue:3 Volume:122 Page:341-345
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Neuvonen Mikko¹,Tarkiainen E. Katriina¹,Tornio Aleksi¹,Hirvensalo Päivi¹,Tapaninen Tuija¹,Paile-Hyvärinen Maria¹,Itkonen Matti K.¹,Holmberg Mikko T.¹,Kärjä Vesa²,Männistö Ville T.³,Neuvonen Pertti J.¹,Pihlajamäki Jussi⁴⁵,Backman Janne T.¹,Niemi Mikko¹

Affiliation:

1. Department of Clinical Pharmacology; University of Helsinki and Helsinki University Hospital; Helsinki Finland

2. Department of Pathology; Kuopio University Hospital; Kuopio Finland

3. Department of Medicine; University of Eastern Finland; Kuopio Finland

4. Department of Public Health and Clinical Nutrition; University of Eastern Finland; Kuopio Finland

5. Clinical Nutrition and Obesity Center; Kuopio University Hospital; Kuopio Finland

Funder

European Research Council

University-Level Health Research and the Sigrid Jusélius Foundation (Helsinki, Finland)

Biomedicum Helsinki-säätiö

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12916/fullpdf

Reference20 articles.

1. The mammalian carboxylesterases: from molecules to functions;Satoh;Annu Rev Pharmacol Toxicol,1998

2. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation;Zhu;J Pharmacol Exp Ther,2013

3. Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans;Tarkiainen;Clin Pharmacol Ther,2015

4. The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response;Lewis;Pharmacogenet Genomics,2013

5. Grapefruit juice inhibits the metabolic activation of clopidogrel;Holmberg;Clin Pharmacol Ther,2014

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