Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans
Author:
Affiliation:
1. Department of Clinical Pharmacology; University of Helsinki and HUSLAB, Helsinki University Hospital; Helsinki Finland
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Reference45 articles.
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4. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol;Tang;J. Pharmacol. Exp. Ther,2006
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