Systematic review with meta-analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis

Author:

Ma C.12ORCID,Guizzetti L.2ORCID,Panaccione R.1,Fedorak R. N.3ORCID,Pai R. K.24ORCID,Parker C. E.2,Nguyen T. M.2,Khanna R.25,Vande Casteele N.26ORCID,D'Haens G.27ORCID,Sandborn W. J.26ORCID,Feagan B. G.258ORCID,Jairath V.258ORCID

Affiliation:

1. Division of Gastroenterology and Hepatology; University of Calgary; Calgary AB Canada

2. Robarts Clinical Trials; Western University; London ON Canada

3. Division of Gastroenterology; University of Alberta; Edmonton AB Canada

4. Department of Pathology and Laboratory Medicine; Mayo Clinic Arizona; Scottsdale AZ USA

5. Department of Medicine; Western University; London ON Canada

6. Division of Gastroenterology; University of California San Diego; La Jolla CA USA

7. Inflammatory Bowel Disease Centre; Academic Medical Centre; Amsterdam The Netherlands

8. Department of Epidemiology and Biostatistics; Western University; London ON Canada

Funder

Institute of Nutrition, Metabolism and Diabetes

Canadian Association of Gastroenterology

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference93 articles.

1. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases;Amiot;Therap Adv Gastroenterol,2015

2. Efficient early drug development for ulcerative colitis;Khanna;Gastroenterology,2016

3. A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis;Su;Gastroenterology,2007

4. Placebo response and remission rates in randomised trials of induction and maintenance therapy for ulcerative colitis;Jairath;Cochrane Database Syst Rev,2017

5. Heterogeneity in definitions of endpoints for clinical trials of ulcerative colitis: a systematic review for development of a core outcome set;Ma;Clin Gastroenterol Hepatol,2017

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