A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe /PSEN1ΔE9 mice-Reference-Cited by-同舟云学术

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A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe /PSEN1ΔE9 mice

Published:2022-02-03 Issue: Volume: Page:
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British J Pharmacology

Author:

Abd‐Elrahman Khaled S.¹²³^ORCID,Sarasija Shaarika¹²,Colson Tash‐Lynn L.¹²,Ferguson Stephen S. G.¹²^ORCID

Affiliation:

1. University of Ottawa Brain and Mind Research Institute Ottawa Ontario Canada

2. Department of Cellular and Molecular Medicine University of Ottawa Ottawa Ontario Canada

3. Department of Pharmacology and Toxicology, Faculty of Pharmacy Alexandria University Alexandria Egypt

Funder

Canadian Institutes of Health Research

Alberta Innovates - Health Solutions

Krembil Foundation

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15750

Reference69 articles.

1. Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex‐selective manner;Abd‐Elrahman K. S.;Science Signaling,2020

2. Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease;Abd‐Elrahman K. S.;Annual Review of Pharmacology and Toxicology,2021

3. mGluR5 contribution to neuropathology in Alzheimer mice is disease stage‐dependent;Abd‐Elrahman K. S.;ACS Pharmacology & Translational Science,2020

4. mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington's disease;Abd‐Elrahman K. S.;Science Signaling,2017

5. Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models;Abd‐Elrahman K. S.;Molecular Brain,2018

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2. Early Cortical Microstructural Changes in Aging Are Linked to Vulnerability to Alzheimer’s Disease Pathology;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging;2024-06

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