A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4 ) gene with severe diabetic retinopathy in type 2 diabetes

Author:

Meng Weihua1ORCID,Shah Kaanan P.2,Pollack Samuela3,Toppila Iiro456,Hebert Harry L.1,McCarthy Mark I.789,Groop Leif10,Ahlqvist Emma10,Lyssenko Valeriya10,Agardh Elisabet10,Daniell Mark11,Kaidonis Georgia12,Craig Jamie E.12,Mitchell Paul13,Liew Gerald13,Kifley Annette13,Wang Jie Jin13,Christiansen Mark W.14,Jensen Richard A.14,Penman Alan15,Hancock Heather A.15,Chen Ching J.15,Correa Adolfo15,Kuo Jane Z.1617,Li Xiaohui1718,Chen Yii-der I.1718,Rotter Jerome I.1718,Klein Ronald19,Klein Barbara19,Wong Tien Y.20,Morris Andrew D.21,Doney Alexander S.F.22,Colhoun Helen M.23,Price Alkes L.3,Burdon Kathryn P.2412,Groop Per-Henrik45625,Sandholm Niina456,Grassi Michael A.26,Sobrin Lucia27,Palmer Colin N.A.28,

Affiliation:

1. Division of Population Health Sciences; Medical Research Institute; Ninewells Hospital and School of Medicine; University of Dundee; Dundee UK

2. Section of Genetic Medicine; Department of Medicine; University of Chicago; Chicago Illinois USA

3. Department of Epidemiology; Harvard T.H.; Chan School of Public Health; Boston Massachusetts USA

4. Folkhälsan Institute of Genetics; Folkhälsan Research Center; Helsinki Finland

5. Abdominal Center; Nephrology; University of Helsinki and Helsinki University Hospital; Helsinki Finland

6. Research Programs Unit; Diabetes and Obesity; University of Helsinki; Helsinki Finland

7. Oxford Centre for Diabetes, Endocrinology and Metabolism; University of Oxford; Churchill Hospital; Headington, Oxford UK

8. Wellcome Trust Centre for Human Genetics; University of Oxford; Oxford UK

9. Oxford NIHR Biomedical Research Centre; Churchill Hospital; Headington, Oxford UK

10. Department of Clinical Sciences; Faculty of Medicine; Lund University; Malmo Sweden

11. Department of Ophthalmology; Royal Melbourne Hospital; Parkville Victoria Australia

12. Department of Ophthalmology; Flinders University; Adelaide South Australia Australia

13. Centre for Vision Research; Department of Ophthalmology and Westmead Institute for Medical Research; University of Sydney C24; Sydney Australia

14. Cardiovascular Health Research Unit; School of Medicine; University of Washington; Seattle Washington USA

15. Department of Ophthalmology; University of Mississippi Medical Center; School of Medicine; University of Mississippi; Jackson Mississippi USA

16. Clinical and Medical Affairs; CardioDx Inc.; Redwood City California USA

17. Institute for Translational Genomics and Population Sciences; Los Angeles Biomedical Research Institute; Harbor-UCLA Medical Center; Torrance California USA

18. Department of Pediatrics; Harbor-UCLA Medical Center; Torrance California USA

19. Department of Ophthalmology and Visual Sciences; University of Wisconsin School of Medicine and Public Health; Madison Wisconsin USA

20. Singapore Eye Research Institute; Singapore National Eye Centre; Yong Loo Lin School of Medicine; National University of Singapore; Ophthalmology and Visual Sciences Academic Clinical Program; Duke-NUS Medical School; Singapore

21. The Usher Institute of Population Health Sciences and Informatics; University of Edinburgh; Edinburgh UK

22. Medical Research Institute; Ninewells Hospital and School of Medicine; University of Dundee; Dundee UK

23. Institute of Genetics and Molecular Medicine; Western General Hospital; University of Edinburgh; Edinburgh UK

24. Menzies Institute for Medical Research; University of Tasmania; Hobart Tasmania Australia

25. Department of Diabetes; Central Clinical School; Monash University; Melbourne Victoria Australia

26. Department of Ophthalmology; University of Illinois at Chicago; Chicago Illinois USA

27. Department of Ophthalmology; Massachusetts Eye and Ear Infirmary; Harvard Medical School; Boston Massachusetts USA

28. Centre for Pharmacogenetics and Pharmacogenomics; Medical Research Institute; Ninewells Hospital and School of Medicine; University of Dundee; Dundee UK

Publisher

Wiley

Subject

Ophthalmology,General Medicine

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