Predicting dosing advantages of factor VIIa variants with altered tissue factor-dependent and lipid-dependent activities
Author:
Affiliation:
1. Center for Theoretical Problems of Physicochemical Pharmacology RAS; Moscow Russia
2. Office of Blood Research and Review; Center for Biologics Evaluation and Research; US Food and Drug Administration; Bethesda MD USA
Funder
US Federal Government, US FDA
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.12628/fullpdf
Reference50 articles.
1. The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis;Hoffman;Semin Hematol,2001
2. A novel FVIIa variant with increased potency and duration of effect compared to wildtype FVIIa. A study in a dog model of hemophilia A;Pittman;Blood,2011
3. Design of a potent phospholipid membrane-dependent factor VIIa variant;Nielsen;J Thromb Haemost,2013
4. Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity;Persson;Proc Natl Acad Sci USA,2001
5. A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia;Allen;Arterioscler Thromb Vasc Biol,2007
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