A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR-Reference-Cited by-同舟云学术

A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR

Published:2022-01-21 Issue: Volume: Page:
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British J Pharmacology

Author:

Liu Jia¹²,Berg Allison P.³^ORCID,Wang Yiting²,Jantarajit Walailak²⁴^ORCID,Sutcliffe Katy J.²^ORCID,Stevens Edward B.¹^ORCID,Cao Lishuang¹^ORCID,Pregel Marko J.³^ORCID,Sheppard David N.²^ORCID

Affiliation:

1. Neuroscience and Pain Research Unit Pfizer Inc. Cambridge UK

2. School of Physiology, Pharmacology and Neuroscience University of Bristol Bristol UK

3. Rare Disease Research Unit Pfizer Inc. Cambridge MA USA

4. Center of Calcium and Bone Research and Department of Physiology, Faculty of Science Mahidol University Bangkok Thailand

Funder

Cystic Fibrosis Trust

Cystic Fibrosis Foundation Therapeutics

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15709

Reference74 articles.

1. Capsaicin Potentiates Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Currents

2. Regulatory Insertion Removal Restores Maturation, Stability and Function of ΔF508 CFTR

3. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

4. Mutation-specific downregulation of CFTR2 variants by gating potentiators

5. Pharmacological therapy for cystic fibrosis: From bench to bedside

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