Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples

Author:

Savage Jeanne E.1ORCID,Salvatore Jessica E.12ORCID,Aliev Fazil23,Edwards Alexis C.14ORCID,Hickman Matthew5,Kendler Kenneth S.146,Macleod John5,Latvala Antti78,Loukola Anu78,Kaprio Jaakko78,Rose Richard J.9,Chan Grace10ORCID,Hesselbrock Victor10,Webb Bradley T.14,Adkins Amy211,Bigdeli Tim B.14,Riley Brien P.16ORCID,Dick Danielle M.2611ORCID

Affiliation:

1. Virginia Institute for Psychiatric and Behavioral Genetics; Virginia Commonwealth University; Richmond Virginia

2. Department of Psychology; Virginia Commonwealth University; Richmond Virginia

3. Faculty of Business; Karabuk University; Karabuk Turkey

4. Department of Psychiatry; Virginia Commonwealth University; Richmond Virginia

5. School of Social and Community Medicine; University of Bristol; Bristol UK

6. Department of Human and Molecular Genetics; Virginia Commonwealth University; Richmond Virginia

7. Institute for Molecular Medicine FIMM; University of Helsinki; Helsinki Finland

8. Department of Public Health; University of Helsinki; Helsinki Finland

9. Department of Psychological and Brain Sciences; Indiana University; Bloomington Indiana

10. Department of Psychiatry; University of Connecticut Health Center; Farmington Connecticut

11. College Behavioral and Emotional Health Institute (COBE); Virginia Commonwealth University; Richmond Virginia

Funder

National Institute of Mental Health

Medical Research Council

National Institute on Alcohol Abuse and Alcoholism

National Institutes of Health

National Cancer Institute

National Center for Research Resources

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Reference65 articles.

1. An integrated map of genetic variation from 1,092 human genomes;Abecasis;Nature,2012

2. Genomewide association study of alcohol dependence identifies risk loci altering ethanol-response behaviors in model organisms;Adkins;Alcohol Clin Exp Res,2017

3. Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence;Ali;Psychiatr Genet,2015

4. American Psychiatric Association 2000 Diagnostic and Statistical Manual of Mental Disorders. 4th ed., text rev American Psychiatric Association Washington, DC

5. GenABEL: An R library for genome-wide association analysis;Aulchenko;Bioinformatics,2007

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