Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms

Author:

Adkins Amy E.12,Hack Laura M.12,Bigdeli Tim B.2,Williamson Vernell S.12,McMichael G. Omari12,Mamdani Mohammed12,Edwards Alexis C.12ORCID,Aliev Fazil12,Chan Robin F.13,Bhandari Poonam3,Raabe Richard C.4,Alaimo Joseph T.4,Blackwell GinaMari G.4,Moscati Arden12,Poland Ryan S.2,Rood Benjamin2,Patterson Diana G.5,Walsh Dermot6,Whitfield John B.7,Zhu Gu7,Montgomery Grant W.7,Henders Anjali K.7,Martin Nicholas G.7,Heath Andrew C.8,Madden Pamela A.F.8,Frank Josef9,Ridinger Monika10,Wodarz Norbert10,Soyka Michael1112,Zill Peter12,Ising Marcus13,Nöthen Markus M.141516,Kiefer Falk17,Rietschel Marcella9,Gelernter Joel18192021,Sherva Richard22,Koesterer Ryan22,Almasy Laura23,Zhao Hongyu2024,Kranzler Henry R.2526,Farrer Lindsay A.2122272829,Maher Brion S.30,Prescott Carol A.31,Dick Danielle M.123,Bacanu Silviu A.12,Mathies Laura D.4,Davies Andrew G.14,Vladimirov Vladimir I.123233,Grotewiel Mike13,Bowers M. Scott124,Bettinger Jill C.14,Webb Bradley T.12,Miles Michael F.134,Kendler Kenneth S.123,Riley Brien P.123ORCID, ,

Affiliation:

1. Virginia Commonwealth University Alcohol Research Center; Virginia Commonwealth University; Richmond Virginia

2. Department of Psychiatry; Virginia Commonwealth University; Richmond Virginia

3. Department of Human & Molecular Genetics; Virginia Commonwealth University; Richmond Virginia

4. Department of Pharmacology & Toxicology; Virginia Commonwealth University; Richmond Virginia

5. Shaftesbury Square Hospital; Belfast United Kingdom

6. Health Research Board; Dublin 2 Ireland

7. Genetic Epidemiology; QIMR Berghofer Medical Research Institute; Royal Brisbane and Women's Hospital; Brisbane Qld Australia

8. Department of Psychiatry; Washington University School of Medicine; St. Louis Missouri

9. Department of Genetic Epidemiology in Psychiatry; Central Institute of Mental Health; Medical Faculty Mannheim/Heidelberg University; Mannheim Germany

10. Department of Psychiatry; University Hospital Regensburg; University of Regensburg; Regensburg Germany

11. Privatklinik Meiringen; Meiringen Switzerland

12. Department of Psychiatry and Psychotherapy; University of Munich; Munich Germany

13. Department of Molecular Psychology; Max-Planck-Institute of Psychiatry; Munich Germany

14. Department of Genomics; Life & Brain Center; University of Bonn; Bonn Germany

15. Institute of Human Genetics; University of Bonn; Bonn Germany

16. German Center for Neurodegenerative Diseases (DZNE); University of Bonn; Bonn Germany

17. Department of Addictive Behavior and Addiction Medicine; Central Institute of Mental Health; Medical Faculty Mannheim/Heidelberg University; Mannheim Germany

18. Department of Psychiatry; Yale University School of Medicine; New Haven Connecticut

19. Department of Neurobiology; Yale University School of Medicine; New Haven Connecticut

20. Department of Genetics; Yale University School of Medicine; New Haven Connecticut

21. Department of Psychiatry; VA CT Healthcare Center; West Haven Connecticut

22. Department of Medicine (Biomedical Genetics); Boston University School of Medicine; Boston Massachusetts

23. Department of Genetics; Texas Biomedical Research Institute; San Antonio Texas

24. Department of Biostatistics; Yale University School of Medicine; New Haven Connecticut

25. Department of Psychiatry; Treatment Research Center; University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania

26. Philadelphia VA Medical Center; VISN 4 MIRECC; Philadelphia Pennsylvania

27. Department of Neurology; Boston University School of Medicine; Boston Massachusetts

28. Department of Ophthalmology; Boston University School of Medicine; Boston Massachusetts

29. Department of Epidemiology; Boston University School of Public Health; Boston Massachusetts. Department of Biostatistics; Boston University School of Public Health; Boston Massachusetts

30. Department of Mental Health; Johns Hopkins Bloomberg School of Public Health; Baltimore Maryland

31. Department of Psychology; University of Southern California; Los Angeles California

32. Lieber Institute for Brain Development; Johns Hopkins University; Baltimore Maryland

33. Center for Biomarker Research and Personalized Medicine; School of Pharmacy; Virginia Commonwealth University; Richmond Virginia

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute of Mental Health

Wellcome Trust

National Institutes of Health

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

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