Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4‐ROS‐ADAM17 pathway

Author:

Zeng Si‐yu1ORCID,Yang Li2,Lu Hui‐qin1,Yan Qiu‐jiang3,Gao Ling4,Qin Xu‐ping2

Affiliation:

1. Department of Drug Clinical Trial Guangdong Second Provincial General Hospital Guangzhou China

2. Laboratory of Vascular Biology, Institute of Pharmacy and Pharmacology University of South China Hengyang China

3. Department of Cardiac & Thoracic Surgery The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China

4. Department of Pharmacy Guangdong Second Provincial General Hospital Guangzhou China

Funder

Natural Science Foundation of Guangdong Province

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference47 articles.

1. Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling

2. Studies on the chemical constituents of Evodia rutaecarpa (Juss.). Benth;Wang QZ;Yao Xue Xue Bao,2004

3. The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells;Wang GJ;J Pharmacol Exp Ther,1996

4. Involvement of CGRP in the inhibitory effect of rutaecarpine on vasoconstriction induced by anaphylaxis in guinea pig

5. Stimulation of calcitonin gene-related peptide synthesis and release

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