Affiliation:
1. Department of Public Health University of Naples Federico II Naples Italy
2. Department of Clinical Medicine and Surgery, Hematology Unit University of Naples Federico II Naples Italy
Abstract
AbstractClassic Hodgkin lymphoma (cHL) consists of a heterogeneous group of haematological disorders that covers undifferentiated B cell neoplasms originating from germinal centre B cells. The HL molecular characterization still represents an ongoing challenge due to the low fraction of tumour Hodgkin and Reed–Sternberg cells mixed with a plethora of non‐tumour haematological cells. In this scenario, next generation sequencing of liquid biopsy samples is emerging as a useful tool in HL patients' management. In this review, we aimed to overview the clinical and methodological topics regarding the implementation of molecular analysis in cHL, focusing on the role of liquid biopsy in diagnosis, follow‐up, and response prediction.
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Cited by
2 articles.
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