Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma-Reference-Cited by-同舟云学术

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma

Published:2018-05-31 Issue:22 Volume:131 Page:2454-2465
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tiacci Enrico¹,Ladewig Erik²,Schiavoni Gianluca¹,Penson Alex²,Fortini Elisabetta¹,Pettirossi Valentina¹,Wang Yuchun¹,Rosseto Ariele¹,Venanzi Alessandra¹,Vlasevska Sofija³,Pacini Roberta¹,Piattoni Simonetta¹,Tabarrini Alessia¹,Pucciarini Alessandra¹,Bigerna Barbara¹,Santi Alessia¹,Gianni Alessandro M.⁴,Viviani Simonetta⁴,Cabras Antonello⁵,Ascani Stefano¹,Crescenzi Barbara¹,Mecucci Cristina¹,Pasqualucci Laura³,Rabadan Raul²,Falini Brunangelo¹

Affiliation:

1. Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy;

2. Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, NY;

3. Institute for Cancer Genetics and the Department of Pathology and Cell Biology, Columbia University, New York, NY;

4. Medical Oncology and

5. Anatomic Pathology, National Cancer Institute, Milan, Italy

Abstract

Key Points Identification of genes frequently mutated in cHL, fostering tumor growth in a manner amenable to pharmacological targeting. Mutated genes include the almost ubiquitous targeting of JAK-STAT pathway members, as well as GNA13, XPO1, and ITPKB.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/22/2454/1468551/blood814913.pdf

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