Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis

Author:

Bajaj Jasmohan S.1ORCID,Kakiyama Genta1,Zhao Derrick1,Takei Hajime2,Fagan Andrew1,Hylemon Phillip1,Zhou Huiping1,Pandak William M.1,Nittono Hiroshi2,Fiehn Oliver3,Salzman Nita4,Holtz Mary4,Simpson Pippa4,Gavis Edith A.1,Heuman Douglas M.1,Liu Runping1,Kang Dae Joong1,Sikaroodi Masoumeh5,Gillevet Patrick M.5

Affiliation:

1. Virginia Commonwealth University and McGuire VA Medical Center; Richmond Virginia

2. Junshin Clinic Bile Acid Institute; Tokyo Japan

3. West Coast Metabolomics Center; Davis California

4. Medical College of Wisconsin; Milwaukee Wisconsin

5. George Mason University; Manassas Virginia

Funder

Veterans Affairs Merit Review

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Reference35 articles.

1. Ethanol has an acute effect on bile acid biosynthesis in man;Axelson;FEBS Lett,1991

2. Decompensated cirrhosis and gut microbiome;Bajaj;Nature,2015

3. Altered profile of human gut microbiome is associated with cirrhosis and its complications;Bajaj;J Hepatol,2014

4. Babor TF Higgins-Biddle JC Saunders JB Monteiro MG 2001 AUDIT: The Alcohol Use Disorders Identification Test Guidelines for Use in Primary Care http://apps.who.int/iris/bitstream/10665/67205/1/WHO_MSD_MSB_01.6a.pdf

5. Taurine increases bile acid pool size and reduces bile saturation index in the hamster;Bellentani;J Lipid Res,1987

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