Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2Areceptor-Reference-Cited by-同舟云学术

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Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2Areceptor

Published:2013-06-12 Issue:5 Volume:169 Page:988-998
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Bertheleme Nicolas¹,Singh Shweta¹,Dowell Simon J²,Hubbard Julia³,Byrne Bernadette¹

Affiliation:

1. Division of Molecular Biosciences; Imperial College London; London; UK

2. Department of Biological Reagent and Assay Development; GlaxoSmithKline; Stevenage; UK

3. Department of Computational and Structural Chemistry; GlaxoSmithKline; Stevenage; UK

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12165/fullpdf

Reference38 articles.

1. [(3)H]ZM241385 - an antagonist radioligand for adenosine A(2A) receptors in rat brain;Alexander;Eur J Pharmacol,2001

2. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids;Brown;J Biol Chem,2003

3. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor;Cherezov;Science,2007

4. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist;Chien;Science,2010

5. Evolution of three human GPCRs for higher expression and stability;Dodevski;J Mol Biol,2011

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