A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering-Reference-Cited by-同舟云学术

A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering

Published:2022-09-21 Issue:10 Volume:31 Page:
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Yamamoto Taisei¹,Yasuda Satoshi¹²³^ORCID,Kasai Rinshi S.⁴⁵^ORCID,Nakano Ryosuke¹,Hikiri Simon⁶,Sugaya Kanna¹,Hayashi Tomohiko⁷⁸,Ogasawara Satoshi¹²³⁹,Shiroishi Mitsunori¹⁰^ORCID,Fujiwara Takahiro K.¹¹^ORCID,Kinoshita Masahiro¹²⁸¹²^ORCID,Murata Takeshi¹²³

Affiliation:

1. Department of Chemistry, Graduate School of Science Chiba University Chiba Japan

2. Membrane Protein Research Center Chiba University Chiba Japan

3. Molecular Chirality Research Center Chiba University Chiba Japan

4. Institute for Glyco‐core Research (iGCORE) Gifu University Gifu Japan

5. Institute for Life and Medical Sciences Kyoto University Kyoto Japan

6. Graduate School of Engineering Science Osaka University Osaka Japan

7. Interdisciplinary Program of Biomedical Engineering, Assistive Technology, and Art and Sports Sciences, Faculty of Engineering Niigata University Niigata Japan

8. Institute of Advanced Energy Kyoto University Kyoto Japan

9. Institute for Advanced Academic Research Chiba University Chiba Japan

10. Department of Biological Science and Technology Tokyo University of Science Tokyo Japan

11. Institute for Integrated Cell‐Material Sciences (WPI‐iCeMS) Kyoto University Kyoto Japan

12. Center for the Promotion of Interdisciplinary Education and Research Kyoto University Kyoto‐shi Japan

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.4425

Reference50 articles.

1. Drug—target network

2. A methodology for creating thermostabilized mutants of G‐protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering

3. Conformational complexity of G-protein-coupled receptors

4. GPCR Dynamics: Structures in Motion

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