Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA 2 ‐mediated adverse reactions? A combined epidemiological‐experimental approach-Reference-Cited by-同舟云学术

Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA 2 ‐mediated adverse reactions? A combined epidemiological‐experimental approach

Published:2021-03-24 Issue:10 Volume:87 Page:3813-3824
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Brit Jnl Clinical Pharma

Author:

Dubrall Diana¹²^ORCID,Pflock René³,Kosinska Joanna³,Schmid Matthias²,Bleich Markus⁴,Himmerkus Nina⁴,Offermanns Stefan⁵,Schwaninger Markus³^ORCID,Sachs Bernhardt¹⁶^ORCID

Affiliation:

1. Research Department Federal Institute for Drugs and Medical Devices (BfArM) Bonn Germany

2. Institute for Medical Biometry, Informatics and Epidemiology University Hospital Bonn Bonn Germany

3. Institute for Experimental and Clinical Pharmacology and Toxicology University of Lübeck Lübeck Germany

4. Institute of Physiology Christian‐Albrechts‐University Kiel Kiel Germany

5. Department of Pharmacology Max Planck Institute for Heart and Lung Research Bad Nauheim Germany

6. Clinic for Dermatology and Allergology University Hospital (RWTH) Aachen Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14787

Reference46 articles.

1. Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

2. Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

3. Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

4. Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

5. Dimethyl Fumarate: A Review in Relapsing-Remitting MS

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