Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity

Author:

Zhou X.1,Weeks S. D.2,Ameloot P.34,Callewaert N.34,Strelkov S. V.2,Declerck P. J.1

Affiliation:

1. Department of Pharmaceutical and Pharmacologic Sciences; Laboratory for Therapeutic and Diagnostic Antibodies; KU Leuven Belgium

2. Department of Pharmaceutical and Pharmacologic Sciences; Laboratory for Biocrystallography; KU Leuven Belgium

3. Flanders Institute for Biotechnology; Medical Biotechnology Center; Ghent Belgium

4. Department of Biochemistry and Microbiology; Laboratory for Protein Biochemistry and Biomolecular Engineering; Ghent University; Ghent Belgium

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Wiley

Subject

Hematology

Reference44 articles.

1. Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N;Hendriks;J Clin Chem Clin Biochem,1989

2. An arginine specific carboxypeptidase generated in blood during coagulation or inflammation which is unrelated to carboxypeptidase N or its subunits;Campbell;Biochem Biophys Res Commun,1989

3. Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma;Eaton;J Biol Chem,1991

4. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex;Bajzar;J Biol Chem,1996

5. Proteolytic activation of purified human procarboxypeptidase U;Schatteman;Clin Chim Acta,2000

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