Gastric and Duodenal Anti-ulcer Activity of SKF 38393, a Dopamine D1-Receptor Agonist in Rats

Author:

Desai Jagruti K1,Goyal Ramesh K1,Parmar Narayan S2

Affiliation:

1. Department of Pharmacology, L.M. College of Pharmacy, Navrangpura, Ahmedabad 380 009, India

2. B.N. College of Pharmaceutical Sciences, Udaipur 313 001, India

Abstract

Abstract The effect of SKF 38393 (1-phenyl-7,8-diol-2,3,4,5-tetrahydro-1H-3-benzazepine), a specific dopamine D1-receptor agonist, was studied on pylorus-ligation and water immersion plus restraint stress-induced gastric ulcers, and cysteamine-induced duodenal ulcers in rats. Repeated administration of SKF 38393 (5 and 10 mg kg−1, p.o.) for six days was found to be effective in the prevention of gastric ulceration induced by water immersion plus restraint stress in rats. In 19-h pylorus-ligated rats, repeated treatment with SKF 38393 showed a significant reduction in the number and severity of ulcers. SKF 38393 did not alter the total gastric-mucosal carbohydrates: protein ratio; however, the gastric content volume and the free and total acidity were significantly reduced. In cysteamine-induced duodenal ulcers, the treatment with SKF 38393 for 6 days prevented the duodenal lesions. Our data suggests the involvement of dopamine D1 receptors in the anti-ulcer activity of SKF 38393, which could be largely attributed to its anti-secretory effect. Its anti-ulcer activity against water immersion plus restraint, also points towards a central mode of action, but its failure to alter the carbohydrate: protein ratio rules out any protective effect through the strengthening of the gastric mucosal barrier.

Funder

J. K. Desai from the Council of Scientific and Industrial Research, New Delhi, India.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference33 articles.

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4. Effect of sulpiride, a dopamine receptor antagonist, on experimentally induced gastric and duodenal ulcers in rats;Desai;Agents Actions,1994

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