From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
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Published:2023-12-07
Issue:12
Volume:16
Page:1699
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ISSN:1424-8247
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Container-title:Pharmaceuticals
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language:en
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Short-container-title:Pharmaceuticals
Author:
Sikiric Predrag1ORCID, Boban Blagaic Alenka1, Krezic Ivan1, Zizek Helena1, Kalogjera Luka1ORCID, Smoday Ivan Maria1, Vukovic Vlasta1ORCID, Oroz Katarina1, Chiddenton Helen Marie1, Buric Sara1, Antunovic Marko1, Gojkovic Slaven1ORCID, Strbe Sanja1, Skocic Milena1, Sikiric Suncana2, Milavic Marija2, Beketic Oreskovic Lidija1, Kokot Antonio3ORCID, Koprivanac Antun1ORCID, Dobric Ivan4, Sever Marko4, Staresinic Mario4, Batelja Vuletic Lovorka2, Skrtic Anita2ORCID, Seiwerth Sven2
Affiliation:
1. Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia 2. Department of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia 3. Department of Anatomy and Neuroscience, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia 4. Department of Surgery, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Abstract
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients. Szabo’s cysteamine duodenal ulcer as the dopamine duodenal healing and cysteamine as a dopamine antagonist signifies the dopamine agonists anti-ulcer effect and dopamine antagonists ulcerogenic effect. From these viewpoints, we focused on dopamine and gastric ulcer healing. We mentioned antecedent studies on the dopamine presence in the stomach and gastric juice. Then we reviewed, in the timeline, therapy significance arising from the anti-ulcer potency of the various dopamine agonists, which is highly prevailing over the quite persistent beneficial evidence arising from the various dopamine antagonists. Meanwhile, the beneficial effects of several peptides (i.e., amylin, cholecystokinin, leptin, and stable gastric pentadecapeptide BPC 157, suggested as an acting mediator of the dopamine brain-gut axis) were included in the dopamine gastric ulcer story. We attempt to resolve dopamine agonists/antagonists issue with the dopamine significance in the stress (cysteamine as a prototype of the duodenal stress ulcer), and cytoprotection (cysteamine in small dose as a prototype of the cytoprotective agents; cysteamine duodenal ulcer in gastrectomized rats). Thereby, along with dopamine agonists’ beneficial effects, in special circumstances, dopamine antagonists having their own ulcerogenic effect may act as “mild stress (or)” or “small irritant” counteracting subsequent strong alcohol or stress procedure-induced severe lesions in this particular tissue. Finally, in the conclusion, as a new improvement in further therapy, we emphasized the advantages of the dopamine agents’ application in lower gastrointestinal tract therapy.
Funder
University of Zagreb, Zagreb, Croatia
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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