Metabolic TV-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations-Reference-Cited by-同舟云学术

Metabolic TV-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations

Published:1976-09 Issue:9 Volume:28 Page:687-691
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Phillipson J D¹,Handa S S¹,Gorrod J W²

Affiliation:

1. Department of Pharmacognosy, The School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, U.K.

2. Department of Pharmacy, Chelsea College, University of London, Manresa Road, Chelsea, London SW3 6LX, U.K.

Abstract

Abstract Incubation of guinea-pig liver microsomal preparations with atropine or hyoscine resulted in the formation of the corresponding nor-alkaloids and both isomers of atropine N-oxide from atropine and one isomer of hyoscine N-oxide from hyoscine. Separate incubations of guinea-pig liver microsomal preparations with nor-atropine and nor-hyoscine yielded the corresponding hydroxylamines. The N-oxide and hydroxylamine metabolites were identified by comparison of their t.l.c. behaviour and m.s. with prepared compounds and also by their reduction to the corresponding tertiary or secondary amines.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/28/9/687/37625326/j.2042-7158.1976.tb02837.x.pdf

Reference25 articles.

1. Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon Atoms

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4. A note on the identification of N-hydroxyphenmetrazine as a metabolic product of phendimetrazine and phenmetrazine

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