A note on the identification of N-hydroxyphenmetrazine as a metabolic product of phendimetrazine and phenmetrazine

Author:

BECKETT A H1,SALAMI M A1

Affiliation:

1. Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, S.W.3., UK

Abstract

Abstract Phenmetrazine and the N-oxide of phendimetrazine have been demonstrated as metabolites in urine in man after oral phendimetrazine (Beckett & Watson, to be published). Recently, in studies of the in vitro metabolism of phenmetrazine and phendimetrazine by liver microsomes of various animal species, we observed a new product in high yields which could be separated from both amines by g.l.c. and t.l.c.; the new metabolic product gave a black spot on t.l.c. when sprayed with ammoniacal silver nitrate. The structure and characteristics of this new metabolic product are now reported.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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