A note on the identification of N-hydroxyphenmetrazine as a metabolic product of phendimetrazine and phenmetrazine

Abstract

Abstract Phenmetrazine and the N-oxide of phendimetrazine have been demonstrated as metabolites in urine in man after oral phendimetrazine (Beckett & Watson, to be published). Recently, in studies of the in vitro metabolism of phenmetrazine and phendimetrazine by liver microsomes of various animal species, we observed a new product in high yields which could be separated from both amines by g.l.c. and t.l.c.; the new metabolic product gave a black spot on t.l.c. when sprayed with ammoniacal silver nitrate. The structure and characteristics of this new metabolic product are now reported.