Affiliation:
1. Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal 576 119, India
Abstract
Abstract
Earlier studies showed that curcumin is a potent inhibitor of iron-catalysed lipid peroxidation. Demethoxycurcumin, bisdemethoxycurcumin and acetylcurcumin were tested for their ability to inhibit iron-stimulated lipid peroxidation in rat brain homogenate and rat liver microsomes. Comparison of the results with curcumin showed that all compounds are equally active, and more potent than α-tocopherol. These results showed that the methoxy and phenolic groups contribute little to the activity. Spectral studies showed that all compounds could interact with iron. Thus, the inhibition of iron-catalysed lipid peroxidation by curcuminoids may involve chelation of iron.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference24 articles.
1. Pharmacology of curcumin;Ammon;Planta Medica,1991
2. The involvement of iron in lipid peroxidation: importance of ferrous to ferric ratios in initiation;Braughler;J. Biol. Chem.,1986
3. Inhibitory effect of curcumin and some related dietary compounds on tumour promotion and arachidonic acid metabolism in mouse skin;Conney,1990
4. Comparison of antioxidative activity of some acid-phenols: structure-activity relationship;Cuvelier;Biosci. Biotech. Biochem.,1992
5. Microsomal lipid peroxidation;Ernster,1967
Cited by
352 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献