The serum amyloid P response in the mouse air pouch-Reference-Cited by-同舟云学术

The serum amyloid P response in the mouse air pouch

Published:1988-03 Issue:3 Volume:40 Page:227-228
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bottomley K M K¹,Rising T J¹,Steward A¹

Affiliation:

1. Department of Drug Discovery, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK

Abstract

Abstract Levels of the acute phase reactant serum amyloid P (SAP) have been measured in the mouse pouch model of rheumatoid arthritis. Implantation of cartilage resulted in a significant and rapid elevation in the SAP concentration, which remained high for the duration of the experiment (14 days). Initial studies with several clinically employed antirheumatic drugs indicated that dexamethasone and cyclosporin A had a marked inhibitory effect.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/3/227/37546264/j.2042-7158.1988.tb05232.x.pdf

Reference11 articles.

1. Acute phase response is a model of chronic inflammation;Al-Duaij,1986

2. Indomethacin, D-penicillamine and dexamethasone in a model of cartilage breakdown by a granulomatous reaction.;Al-Duaij;Br. J. Pharmacol.,1986

3. Models of arthritis and the search for anti-arthritic drugs;Billingham;Pharmacology,1983

4. Cartilage degradation in a mouse air pouch model, Br.;Bottomley;J. Pharmacol.,1986

5. Interleukin 1 and the pathogenesis of the acute phase response.;Dinarello;New. Eng. J. Med.,1984

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