Protein binding of cefpiramide in the plasma of various species-Reference-Cited by-同舟云学术

Protein binding of cefpiramide in the plasma of various species

Published:1991-11 Issue:11 Volume:43 Page:805-806
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ohshima Taeyuki¹,Hasegawa Takaaki¹,Johno Ikuo²,Kitazawa Shikifumi³

Affiliation:

1. Department of Hospital Pharmacy, School of Medicine, Nagoya University, Nagoya 466, Japan

2. Pharmacy Services, Kishiwada City Hospital, Kishiwada 596, Japan

3. Department of Hospital Pharmacy, Keio University Hospital, Tokyo 160, Japan

Abstract

Abstract The plasma protein binding of cefpiramide in man, dog, rabbit and rat was examined. Cefpiramide was more strongly bound to human plasma than to animal plasma and was exclusively bound to albumin. The characteristics of the protein binding of cefpiramide is one of the factors influencing the extrapolation of drug disposition from animals to man.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/43/11/805/37240215/j.2042-7158.1991.tb03487.x.pdf

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