Author:
Fukasawa M,Noguchi H,Okuda T,Komatsu T,Yano K
Abstract
SM-1652 (sodium 7-[D(-)-alpha-(4-hydroxy-6-methylpyridine-3-carboxamido)-alpha-(4-hydroxyphenyl)acetamido]-3-[(1-methyl-1H-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylate) is a new semisynthetic cephalosporin derivative with a broad spectrum of antibacterial activity. Its in vitro activity against gram-positive bacteria was comparable to that of cefazolin. SM-1652 exceeded cefazolin in potency and broadness of antibacterial activity against such Enterobacteriaceae as indole-positive Proteus spp., Enterobacter cloacae, and Serratia marcescens. A remarkable feature of the spectrum of SM-1652 is its high activity against Pseudomonadaceae. Against 200 clinical isolates of Pseudomonas aeruginosa, SM-1652 was significantly more active than cefoperazone, cefotaxime, and sulbenicillin and as active as cefsulodin. The activities of SM-1652 against Pseudomonas maltophilia and Pseudomonas cepacia were superior to those of cefoperazone, cefotaxime, cefsulodin, sulbenicillin, and gentamicin. SM-1652 was relatively stable to hydrolysis with plasmid-mediated penicillinases and cephalosporinases produced by gram-negative bacteria.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. Experimental evaluation of HR-756 a new cephalosporin derivative: pre-clinical study;Heymes R.;Infection,1977
2. Komatsu T. T. Okuda H. Noguchi M. Fasawa K. Yano M. Kato and S. Mltnabl. 1980. SM-1652 a new parenterally active cephalosporin: microbiological studies p. 275-278. In J. D. Nelson and C. Grassi (ed.) Current chemotherapy and infectious disease. American Society for Microbiology Washington D.C.
3. Protein measurement with the Folin phenol reagent;Lowry 0.;J. Biol. Chem.,1951
4. In vitro antibacterial activity of.cefoperazone (T-1551), a new semisynthetic cephalosporin;Mataba N.;Antimicrob. Agents Chemother.,1979
5. Purification and some properties of a cephalosporinase from Proteus vulgaris;YotsWjl KK.;Antimicrob. Agents Chemother.,1981
Cited by
27 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献