Affiliation:
1. Department of Pharmaceutics, M/C 880, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
Abstract
Abstract
Complex coacervation between oppositely charged albumin and acacia mixtures has been studied, and the applicability of the various theoretical treatments of complex coacervation (the Voorn-Overbeek, Veis-Aranyi, Nakajima-Sato, and Tainaka theories) to this system has been assessed. Under optimum conditions where maximum coacervate yield occurred, the Voorn-Overbeek theory appeared to apply. However, away from the optimum coacervation conditions, coacervate sol formation was observed, which is in accordance with the Veis-Aranyi and Tainaka theories. Microelectrophoretic measurements were used to determine optimum pH and ionic strength conditions for maximum coacervation, based on the method of Burgess & Carless (1984). The effects of pH and ionic strength on coacervate yield are reported. Around the optimum conditions for maximum coacervation a viscous coacervate phase and a relatively clear equilibrium phase are formed.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference20 articles.
1. Practical analysis of complex coacervate systems;Burgess;J. Colloid Interface Sci.,1991
2. Microelectrophoretic studies of gelatin and acacia for the prediction of complex coacervation;Burgess;Ibid.,1984
3. Manufacture of gelatin/gelatin coacervate microcapsules;Burgess;Int. J. Pharm.,1985
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