Affiliation:
1. The School of Pharmacy, University of London, Brunswick Square, London WC1N 1AX, UK
Abstract
Abstract
Experimentally determined concentrations of butobarbitone, and three or its metabolites, in the urine of two volunteers, have been studied using a computer technique, which tests the data for limited capacity or first order kinetics. In both volunteers, the 3′-hydroxy and the 3′-oxo metabolites follow limited capacity kinetics for the first few days of excretion, and unchanged butobarbitone follows first order kinetics. Differing results were found for the two persons with the 3′-carboxylic acid metabolite. An additional calculation is proposed when applying the Levy method for interpreting limited capacity kinetics to data where drug recovery is incomplete.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
7 articles.
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