Affiliation:
1. The School of Pharmacy, 29/39 Brunswick Square, London WC1N 1AX, U.K.
Abstract
Abstract
The urinary excretion of secbutobarbitone (I) and its metabolites has been studied quantitatively using combined gas chromatographymass spectrometry. After a single oral dose was given to healthy male volunteers, unchanged drug (5–9%), 2′-hydroxysecbutobarbitone (II, 1·7–3·2%), 2′-oxosecbutobarbitone (III, less than 1%), and the carboxylic acid (IV, 24–34%) were found. The kinetics of the excretion process were studied.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献