A comparison of the incorporation of model steroids into non-ionic micellar and microemulsion systems-Reference-Cited by-同舟云学术

A comparison of the incorporation of model steroids into non-ionic micellar and microemulsion systems

Published:1993-02 Issue:2 Volume:45 Page:141-143
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Malcolmson Carole¹,Lawrence M Jayne¹

Affiliation:

1. Department of Pharmacy, King’s College London, Manresa Road, London SW3 6LX, UK

Abstract

Abstract The incorporation of testosterone and two of its esters, and progesterone and one of its esters (log Poct varying from 3·3 to 6·9) into 2% w/w soybean oil/Brij 96 microemulsions and Brij 96 surfactant systems has been examined. Possible sites of incorporation have been investigated. The drug carrying improvement of an oil-in-water microemulsion over a micellar system appears to depend on the solubility of the drug in the dispersed oil phase and is significant only for very lipophilic drugs.

Funder

Royal Pharmaceutical Society of Great Britain

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/45/2/141/37244798/j.2042-7158.1993.tb03700.x.pdf

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2. Drug Compendium;Craig,1990

3. Solubilization of griseofulvin by nonionic surfactants;Elworthy;J. Pharm. Pharmacol.,1968