A new approach to prostate cancer-Reference-Cited by-同舟云学术

A new approach to prostate cancer

Published:1989-07 Issue:7 Volume:41 Page:488-489
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ito Yoshikazu Z¹,Nakazato Yoichi¹,Petrow Vladimir²

Affiliation:

1. College of Medical Care and Technology, Gunma University, Department of Pathology, Gunma University School of Medicine, Maebashi, Gunma 371, Japan

2. Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA

Abstract

Abstract Growth of androgen-dependent human prostatic adenocarcinoma implanted in the nude mouse (Honda tumour), is inhibited by 6-methyleneprogesterone. This steroid is a potent inhibitor of both rat and human prostatic 5α-reductase in-vitro. In-vivo, at the studied dose level, it reduces metabolic conversion of testosterone to dihydrotestosterone with minimal effects upon circulating LH and testosterone. These data support the hypothesis that dihydrotestosterone and not testosterone is the main trophic androgen of the human prostatic neoplasm.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/7/488/37235759/j.2042-7158.1989.tb06507.x.pdf

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1. The Role of 5α-Reductase in Prostate Disease and Male Pattern Baldness;Androgens and Androgen Receptor;2002

2. 6-methylene progesterone is cytotoxic to human cancer cell lines independent of its 5-α-reductase activity;The Prostate;1995-01

3. Comparison of testosterone metabolism in benign prostatic hyperplasia and human prostate cancer cell lines in vitro;The Journal of Steroid Biochemistry and Molecular Biology;1994-08

4. LY207320 (6-methylene-4-pregnene-3,20-dione) inhibits testosterone biosynthesis, androgen uptake, 5α-reductase, and produces prostatic regression in male rats;The Prostate;1993