The anticoagulant activity of some selected warfarin analogues-Reference-Cited by-同舟云学术

The anticoagulant activity of some selected warfarin analogues

Published:1987-02 Issue:2 Volume:39 Page:142-144
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Obaseki Andrew O¹,Coker Herbert B²

Affiliation:

1. Department of Biopharmacy & Clinical Pharmacy, School of Pharmacy, College of Medicine, University of Lagos, Lagos, Nigeria

2. Department of Pharmaceutical Chemistry, School of Pharmacy, College of Medicine, University of Lagos, Lagos, Nigeria

Abstract

Abstract The anticoagulant activities of 6-, 7-, 8-, 4′-hydroxy, 6-chloro- and 6-bromowarfarin were determined in rabbits after intraperitoneal administration of 16.2 μmol kg−1 over 96 h. Substitution on the 4-hydroxycoumarin moiety resulted in reduction of the anticoagulant activity. 6-Chlorowarfarin was more potent than 6-bromowarfarin suggesting that the molecular size of 4-hydroxycoumarin moiety may be crucial for biological activity.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/39/2/142/37543486/j.2042-7158.1987.tb06964.x.pdf

Reference12 articles.

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2. A new warfarin metabolite: structure and function

3. 4-Hydroxycoumarins. Synthesis of the metabolites and some other derivatives of warfarin

4. Warfarin metabolism in man: identification of metabolites in urine

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