Enhancement of nasal absorption of insulin and calcitonin using polyacrylic acid gel

Abstract

Abstract The effects of polyacrylic acid gel on the nasal absorption of insulin and [Asusup>1,7]-eel calcitonin were investigated in rats. The nasal administration of insulin (1 IU kgsup>−1) in polyacrylic acid gel at 0.1 and 1% w/v showed maximum hypoglycaemic effects at 30 min and 1 h after administration, respectively. However, the nasal administration of insulin in carboxymethyl cellulose (1% w/v) solution had no hypoglycaemic effect at the same dose. When [Asu1.7]-eel calcitonin (10 U kg−1) was administered nasally in polyacrylic acid gel (0.1% w/v), a prominent hypocalcaemic effect was observed during the first 30 min. Nasal administration of [Asu1,7]-eel calcitonin in saline had no hypocalcaemic effect at the same dose. The results indicate that the polyacrylic acid gel base significantly enhanced the absorption of insulin and [Asu1,7]-eel calcitonin via the nasal cavity.