Affiliation:
1. Central Research Division, Takeda Chemical Industries Ltd., Osaka, Japan
Abstract
The Intranasal application of an Insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemie. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
115 articles.
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