19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine-Reference-Cited by-同舟云学术

19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine

Published:1985-12 Issue:12 Volume:37 Page:869-873
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Everett J R¹,Jennings K¹,Woodnutt G¹

Affiliation:

1. Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Brockham Park, Betchworth, Surrey, UK

Abstract

Abstract 19F NMR spectroscopy was used to monitor the metabolites of flucloxacillin in the urine of a rat dosed with its sodium salt. 19F NMR signals were detected and quantified from flucloxacillin and three metabolites. The 19F NMR method involves minimal sample preparation and is free from interference by endogenous urine components. High-field spin-echo 1H NMR spectroscopy and HPLC were used to confirm the results.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/12/869/37533014/j.2042-7158.1985.tb04991.x.pdf

Reference11 articles.

1. Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine.

2. Structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids

3. Spin-echo 1H n.m.r. spectroscopy: a new method for studying penicillin metabolism

4. Epimerization of Benzylpenicilloic Acid in Alkaline Media

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