Structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids-Reference-Cited by-同舟云学术

Structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids

Published:1983-03 Issue:3 Volume:35 Page:138-143
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bird A E¹,Cutmore E A¹,Jennings K R¹,Marshall A C¹

Affiliation:

1. Beecham Pharmaceuticals Research Division, Chemotherapeutic Research Division, Chemotherapeutic Research Centre, Brockham Park, Betchworth, Surrey, RH3 7AJ, U.K.

Abstract

Abstract Products formed in-vitro from ampicillin and amoxycillin penicilloates have been examined by high-performance liquid chromatography, ultraviolet and nuclear magnetic resonance spectroscopy and thiol group determination and were found to be the 5S epimers of the penicilloic acids. This is in contrast to a published claim that the corresponding penamaldic acids were formed by the treatment used.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/35/3/138/37623221/j.2042-7158.1983.tb04292.x.pdf

Reference16 articles.

1. Piperazinedione formation from reaction of ampicillin with carbohydrates and alcohols in aqueous solution

2. Determination of the configuration of the four D-benzylpenicilloates

3. Base-catalyzed hydrolysis of 6-aminopenicillanic acid. The kinetic and thermodynamic products

4. A nuclear magnetic resonance study of the degradation of penicillin G in acidic solution

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