Preventive Effects of Unsei-in and Oren-gedoku-to, Chinese Traditional Medicines, Against Rat Paw Oedema and Abdominal Constriction in Mice-Reference-Cited by-同舟云学术

Preventive Effects of Unsei-in and Oren-gedoku-to, Chinese Traditional Medicines, Against Rat Paw Oedema and Abdominal Constriction in Mice

Published:1996-03 Issue:3 Volume:48 Page:327-331
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Wang L M¹,Mineshita S¹

Affiliation:

1. Department of Preventive Medicine, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113, Japan

Abstract

Abstract Oren-gedoku-to and Unsei-in are complex mixtures of ingredients derived from plants. These two drugs are clinically most frequently used in the treatment of Behçet's disease, we have investigated the anti-inflammatory and analgesic actions of Oren-gedoku-to and Unsei-in using a battery of tests; rat paw oedema induced by five different agents; abdominal constriction; mouse ear swelling; and dye leakage tests, designed to clarify the therapeutic potential of these medicines. The findings in this study that these medicines are able to inhibit the rat paw oedema, suppress the abdominal constriction and inhibit the increased dye permeability confirm the analgesic and anti-inflammatory effects of these compounds. From these results there seems a clear rationale for exploring the effectiveness of these Chinese medicines in the treatment øf chronic and acute inflammatory diseases.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/48/3/327/37015295/j.2042-7158.1996.tb05927.x.pdf

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