Affiliation:
1. Department of Pharmacology, Anadolu University, Eskisehir 26470, Turkey
2. Department of Pharmacognosy, Faculty of Pharmacy and Medicinal and Aromatic Plant and Drug Research Centre (TBAM), Anadolu University, Eskisehir 26470, Turkey
Abstract
Abstract
The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nuda, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5°C) methods.
Of the species studied, only N. caesarea showed significant analgesic activity, besides marked sedation, which was also blocked by naloxone, indicating involvement of opioid receptors. Moreover, it was only active on mechanical, not thermal, algesic response which suggests specificity for specific opioid receptor subtypes, excluding μ-opioid receptors.
Because 4aα,7α,7aα-nepetalactone is the main component of the essential oil of N. caesarea, and is present at very high levels (92–95%), it is concluded that 4aα,7α,7aα-nepetalactone is the active principle and has a specific opioid receptor subtype agonistic activity.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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